Archive for the ‘immunology retractions’ Category
The article, “Exvivo experiments of human ovarian cancer ascites-derived exosomes presented by dendritic cells derived from umbilical cord blood for immunotherapy treatment,” purported to show that:
tumor-specific antigens present on exosomes can be presented by DCs [dendritic cells] derived from unrelated umbilical cord blood to induce tumor specific cytotoxicity and this may represent as a novel immunotherapy for ovarian cancer.
But according to William C. S. Cho, editor of the journal, there’s reason to doubt the conclusions. As the notice explains:
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All the notice for “Simultaneous expression of antibody light and heavy chains in Pichia pastoris: improving retransformation outcome by linearizing vector at a different site,” published in Applied Microbiology and Biotechnology, says is: Read the rest of this entry »
Rui Curi — the Brazilian scientist who threatened to sue the now-shuttered Science-Fraud.org site for criticizing his work — has rung up his second retraction, this one for a paper that he corrected earlier this year.
Here’s the Journal of Endocrinology notice, whose headers and language are a bit confusing, understandably, because it is retracting two things, a correction and the original paper: Read the rest of this entry »
Former National University of Singapore and University of Liverpool scientist Alirio Melendez has two more of the 20-something retractions suggested by the investigations into his work. Both appear in the Journal of Biological Chemistry.
PLOS ONE has issued a fascinating expression of concern about data collection in a paper it published late last year on the possible spread of deadly viruses among Indonesian orangutans. The case has been brought to the attention of the Indonesian government, but more on that in a moment.
The article, published last July by an international group of primate scientists led by Chairul Nidom, a virologist at Indonesia’s Airlangga University, sounded an alarm about “wild” orangutans in Borneo: Blood tests of 353 “healthy” animals showed antibodies for viruses akin to Ebola. What’s more, the filoviruses viruses to which the antibodies responded, as New Scientist and other outlets reported when the original paper came out, included strains not previously seen outside Africa (as well as Marburg, another deadly infection).
A team of Swiss microbiologists has retracted their 2012 paper in PLoS One on the genetics of the TB mycobacterium after learning that the fusion protein they thought they’d used in their study was in fact a different molecule.
Here’s the retraction notice for the article, “A β-lactamase based reporter system for ESX dependent protein translocation in mycobacteria,” which has been cited once, according to Thomson Scientific’s Web of Knowledge: Read the rest of this entry »
Alirio Melendez, a former National University of Singapore immunologist whose story we’ve been following here since a retraction in September of last year, committed misconduct on an “unprecedented” scale, according to the university, involving more than 20 papers.
Nature’s Richard van Noorden has the scoop:
After a 19-month investigation, the National University of Singapore (NUS) today says that it has determined that one of its former scientists, the immunologist Alirio Melendez, has committed “serious scientific misconduct”. The university found fabrication, falsification or plagiarism associated with 21 papers, and no evidence indicating that other co-authors were involved in the misconduct, it says.