Archive for the ‘not reproducible’ Category
Why I retracted my Nature paper: A guest post from David Vaux about correcting the scientific record
Last month, Ivan met David Vaux at the 3rd World Conference on Research Integrity in Montreal. David mentioned a retraction he published in Nature, and we thought it would be a great guest post on what it’s like to retract one of your own papers in an attempt to clean up the literature.
In September 1995 Nature asked me to review a manuscript by Bellgrau and co-workers, which subsequently appeared. I was very excited by this paper, as it showed that expression of CD95L on Sertoli cells in allogeneic mismatched testes tissue transplanted under the kidney capsule was able to induce apoptosis of invading cytotoxic T cells, thereby preventing rejection. As I wrote in a News and Views piece, the implications of these findings were enormous – grafts engineered to express CD95L would be able to prevent rejection without generalized immunosuppression.
In fact, I was so taken by these findings that we started generation of transgenic mice that expressed CD95L on their islet beta cells to see if it would allow islet cell grafts to avoid rejection and provide a cure for diabetes in mismatched recipients.
Little did we know that instead of providing an answer to transplant rejection, these experiments would teach us a great deal about editorial practices and the difficulty of correcting errors once they appear in the literature. Read the rest of this entry »
The authors of a paper on quorum sensing — in simple terms, how bacteria “talk” to one another — have retracted it after another group’s findings led them to discover that the mixture they used weren’t what they thought.
Doing the right thing: Psychology researchers retract after realizing data “were not analyzed properly”
Amid an ongoing investigation, a group of psychology researchers at the University of Leuven (KU Leuven) in Belgium have taken a painful decision to retract a paper now that they’ve realized there were serious problems with one aspect of the work.
Here’s the notice for “The Emergence of Orthographic Word Representations in the Brain: Evaluating a Neural Shape-Based Framework Using fMRI and the HMAX Model,” by Wouter Braet, Jonas Kubilius, Johan Wagemans, and Hans P. Op de Beeck: Read the rest of this entry »
No, not that Madoff.
We’re talking about Robert Madoff, editor of Diseases of the Colon & Rectum. His journal is pulling a 2012 paper by a group of authors in Spain who seem to have been unable to back up their findings when they were found to contain errors.
The article, “Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches?” looked at what evidently is a significant side effect of nitroglycerin treatment for anal fissures: headaches. According to the abstract:
Here’s the retraction notice for “Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling,” by Liqun Wu and colleagues of The Affiliated Hospital of Medical College, QingDao University, in China’s Shan Dong Province: Read the rest of this entry »
The journal Heart has retracted a 2012 meta-analysis after learning that two of the six studies included in the review contained duplicated data. Those studies, it so happens, were conducted by one of the co-authors.
The article, “Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis,” came from an eclectic group of authors from the United States, Canada and Italy (the first author is listed as being at a Wegmans pharmacy in Ithaca, N.Y.). The paper, published online in August 2012, purported to find that: Read the rest of this entry »