Cell reviewing allegations of image reuse in human embryonic stem cell cloning paper

Cell is looking into whether the authors of a widely hailed study published last week claiming to have turned human skin cells into embryonic stem cells manipulated images inappropriately, Retraction Watch has learned.

The potential image problems came to light on PubPeer, a site designed to allow for post-publication peer review. A commenter, identified as Peer1, identified “several examples of image reuse which might be of interest to PubPeer members and readers:”

Image correction in Current Biology for Harvard’s Sam Lee

The work of Sam W. Lee, a cancer biologist at Harvard and Massachusetts General Hospital, has come under fire at Science Fraud lately over concerns about the possible reuse of images in his group’s published studies.

Turns out there’s some there, there after all. The journal Current Biology has issued a pretty thorny correction for one of Lee’s 2006 articles, “RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress,” citing multiple issues with its figures:

You’ve been dupe’d: Catching up on authors who liked their work enough to use it again

photo by Mark Turnauckas via Flickr http://www.flickr.com/photos/marktee/

As we’ve noted before, we generally let duplication retractions make their way to the bottom of our to-do pile, since there’s often less of an interesting story behind them, duplication is hardly the worst of publishing sins, and the notices usually tell the story. (These are often referred to — imprecisely — as “self-plagiarism.”)

But that skews what’s represented here — boy, are there a lot of duplication retractions we haven’t covered! — and we might as well be more comprehensive. Plus, our eagle-eyed readers may find issues that we won’t see on a quick scan.

So with this post, we’re inaugurating a new feature here at Retraction Watch, “You’ve been dupe’d.” Every now and then, we’ll gather five of these duplication retractions at a time, and post them so they get into the mix, and into our category listing (see drop-down menu in right-hand column if you haven’t already). Here are the first five:

Glasgow’s Beatson Institute investigating circumstances of Cell retraction for inappropriate images

The Beatson Institute for Cancer Research in Glasgow, Scotland is looking into how inappropriate images ended up in a Cell paper that has just been retracted.

Here’s the notice for the paper by Lynne Marshall, Niall S. Kenneth, and Robert J. White:

An Immunity retraction for Luk van Parijs, three years after the ORI found evidence of fabrication in the paper

Earlier this month, we reported on a correction by Luk van Parijs, the biologist the Massachusetts Institute of Technology (MIT) fired in 2005 after he admitted to making up data.

Immunity has now run a retraction involving van Parijs, dated May 25, 2012, for 2003′s “Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1″:

Cell paper, once plagiarized, pulled for dodgy figures

A while back (last June, to be precise), we wrote about a group of Japanese endocrinologists who found a creative way to up their citation counts using duplicate publication. At the time, the researchers were docked a 2004 paper in the Journal of Steroid Biochemistry & Molecular Biology that had self-plagiarized extensively from a 2003 article in Cell.

Well, skeptics of this new math take heart: The group’s publication total has fallen yet again. Turns out that 2003 paper — which has been cited 160 times, up from 144 when we checked last year, according to Thomson Scientific’s Web of Knowledge — wasn’t quite up to snuff, either.

According to the retraction notice for the article, ”The Chromatin-Remodeling Complex WINAC Targets a Nuclear Receptor to Promoters and Is Impaired in Williams Syndrome:”

Cell runs a lengthy correction, rather than retraction, for image problems

The journal Cell has an interesting — and somewhat puzzling — correction this month that we’ll add to our “mega-correction” file.

At issue is a paper, published in October, from the lab of Harvard’s Stephen Elledge, a noted genetics researcher, whose first author is a post-doc there named Michael Emanuele.

According to the notice, Emanuele (singled out, we note) seems to have been rather careless with the images used in the article, titled “Global Identification of Modular Cullin-RING Ligase Substrates”:

*Savaskan and Nitsch, forced to retract FASEB J paper, correct Cell study with duplicated figure

In August, we wrote about the complicated case of a paper retracted from FASEB Journal that had originally been slated for a correction instead. There had been allegations of misconduct by one of the authors, Nicolai E. Savaskan, and the key parts of the retraction notice for the paper were as follows:

A well-recognized and top-class fact finding commission concluded that the publication contains gross flaws. A key figure (Figure 14) and the conclusions drawn from it could not be underlined with the corresponding primary data.

Savaskan told us at the time that FASEB Journal had agreed to a correction of the figure in question, but ended up retracting the paper after receiving a letter from Annette Gruters-Kieslich at Charite – Universitatsmedizin Berlin, where the work was done. We didn’t get much of an answer from FASEB Journal about why they changed their minds.

*Since understanding why one paper warrants a correction and another gets retracted is important for us at Retraction Watch, a correction of a 2009 Cell paper by a group that included Savaskan and his FASEB J c0-author Robert Nitsch caught our eye. The correction for “Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling” — a paper cited nine times so far, according to Thomson Scientific’s Web of Knowledge – ran in the September 16, 2011 issue of Cell:

Ties that don’t bind: Group retracts parathyroid hormone crystallography paper

The authors of a 2008 paper alleging to have described how a particular protein binds to the parathyroid hormone have retracted it. The paper, “Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ₁₂,” has been cited 12 times, according to Thomson Scientific’s Web of Knowledge. According to the notice:

Another Cell retraction, and more questions than answers

A new retraction has appeared in the journal Cell. The article, “DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance,” had initially appeared in February 2009.

According to the notice: