Archive for the ‘mechanisms of development’ Category
Biologists delete paper from literature after realizing they’d deleted too many genes
Researchers deleted more genes than they bargained for in a Drosophila strain, a mistake that resulted in a retraction of a paper from 2007.
Ron Wides, a biologist specializing in pattern development at Bar-Ilan University, Israel, and colleagues have retracted a paper published in Mechanisms of Development after his lab found that their technique to delete the Ten-a gene ended up deleting other nearby genes, too.
It was deletions of other genes, and not Ten-a, that killed the fruit flies, Wides concluded. His group had also concluded, erroneously, that Ten-a is what’s known as a “pair-rule” gene. Fruit fly embryos develop in stacked segments, like tubes of Pringles; pair-rule genes guide the development of alternating segments. Those other loci, and not Ten-a, caused lethality and caused the flies to develop improperly early, Wides concluded.
