Two Expressions of Concern in Blood for MD Anderson’s Aggarwal, who has threatened to sue Retraction Watch

Bharat Aggarwal, the MD Anderson researcher who has threatened to sue us while under investigation by his institution for alleged misconduct, now has two Expressions of Concern in addition to two corrections and two unexplained withdrawals.

Both of the papers were published in Blood. The Expression of Concern for “Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway,” reads:

ORI rules in longstanding University of Washington misconduct case

Andrew Aprikyan

A case of alleged misconduct at the University of Washington in Seattle may finally be over. The Office of Research Integrity released its findings following an investigation into the work of Andrew Aprikyan, a former hematology researcher at the university.

The Aprikyan case has dragged on for a decade. In 2010, the university fired the scientist after a court denied his appeals based on allegations that they had denied him due process. As the Seattle Times reported at the time: 

Kenji Okajima retraction count grows to five

Kenji Okajima

We’ve been following the case of Kenji Okajima, a professor at Nagoya City University in Japan who was suspended for six months following an investigation into work in his lab. Bits of the story — including at least one other university investigation, and scrutiny of Okajima’s colleagues, one of whom was fired — have been dribbling out for almost two years since a retraction notice in the Journal of Neuroscience.

In all, it looks as Nagoya found evidence of misconduct in 19 papers. The Journal of Neuroscience retraction appeared in 2011, and another showed up in the Journal of Immunology last year. Now there are three more: One in Translational Research and two in Blood.

Here’s the notice from Translational Research:

“Redundant in principle”: Blood retracts paper built on double-dipping of data by co-author

Blood has retracted a 2012 paper by a pair of Swedish authors, one of whom appears to have misappropriated data from his mentor.

The article, titled “Microparticles are the basic storage units for different proteins in platelet granules,” appeared online in July 2012 and was written by Chi Zhang and Yang Yang, of the Royal Institute of Technology in Stockholm.

But as the retraction notice explains, there was a problem:

ORI finds Harvard stem cell lab post-doc Mayack manipulated images

courtesy Nature

Shane Mayack, a former post-doc in Harvard lab of Amy Wagers, a rising star in the stem cell field, has been sanctioned by the Office of Research Integrity for misconduct.

Mayack, who has defended her actions on this blog as honest error — albeit sloppiness — and has not admitted to wrongdoing, must undergo supervision if she receives any federal grant funding over the next three years, under the voluntary agreement.

Here’s the notice, which appeared in the Federal Register this week (and which the Boston Globe was first to report):

A Wnt-er’s tale: Blood pulls second signaling paper from Spanish scientists over image fakery

Blood has pulled a paper 2007 paper from a group of Spanish researchers, one of whom appears to have been manipulating images.

The group’s work became the focus of expressions of concern from the Journal of Clinical Oncology this spring and in 2010.

The article, “Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia,” purported to show “a role of abnormal Wnt signaling in ALL and establish a group of patients with a significantly worse prognosis (methylated group)” and earned a commentary on the significance of the findings.

But as the notice explains, the first author lifted and manipulated a figure from a previously published article:

Two new corrections for Utah group that retracted two Cell Metabolism papers for missing notebooks

We have an update on the case of a University of Utah lab that retracted two Cell Metabolism papers last month after a fired lab technician disposed of two lab notebooks without permission. The team has now corrected two other papers, one in Blood and the other in the Journal of Clinical Investigation.

Here’s the notice from Blood:

Errors force retraction of Blood paper on genetics of Hodgkin’s lymphoma

The authors of a paper published last September in Blood about alleged links between certain genes and Hodgkin’s lymphoma have retracted it, after realizing they’d made mistakes in their calculations.

The retraction notice for “Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups,” dated January 20 and signed by all of the authors, clearly explains what went wrong, taking pains to note that there was no misconduct involved:

Blood retracts stem cell paper from Amy Wagers’ Harvard lab after 14 months of concern

More than 14 months after Blood issued a notice of concern about a paper by a Harvard stem cell scientist and her former post-doc, the journal has retracted the article.

Here’s the notice for the paper, “Osteolineage niche cells initiate hematopoietic stem cell mobilization,” by Shane Mayack and Amy Wagers:

A fifth retraction for Anil Potti, this one in Blood

courtesy Duke

The list of papers retracted by former Duke oncologist Anil Potti has grown to five. The notice, from Blood: