Two Expressions of Concern in Blood for MD Anderson’s Aggarwal, who has threatened to sue Retraction Watch

Bharat Aggarwal, the MD Anderson researcher who has threatened to sue us while under investigation by his institution for alleged misconduct, now has two Expressions of Concern in addition to two corrections and two unexplained withdrawals.

Both of the papers were published in Blood. The Expression of Concern for “Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway,” reads:

MD Anderson’s Bharat Aggarwal inquiry still ongoing; center uninvolved in legal threats

Bharat Aggarwal

When we learned earlier this week that Bharat Aggarwal, the MD Anderson researcher under investigation there for possible misconduct, had directed his attorneys to send us a pull-all-your-posts-about-our-client-or-we’ll-sue-you letter, we wondered if he’d included the Houston institution in that decision.

Turns out he’d been acting on his own.

MD Anderson’s Bharat Aggarwal threatens to sue Retraction Watch

Bharat Aggarwal

Bharat Aggarwal, an MD Anderson researcher under investigation by his institution, has threatened to sue us.

Today, we received a letter from the Houston firm of Paranjpe & Mahadass LLP telling us to pull every post related to their client off our site within 20 days, or they’d “file a lawsuit against” us on his behalf.

On what grounds? According to the March 26 letter, which we have posted here in its entirety:

Scientist whose work is “not fully supported by the available laboratory records” to retract 8 more papers

SK Manna

Yesterday, we reported that Sunil Kumar Manna, the head of immunology at India’s Centre for DNA Fingerprinting and Diagnostics, had retracted two papers for image problems.

Turns out Manna will be retracting eight more, he told us today. Here they are:

Correction for MD Anderson’s Aggarwal, cancer researcher whose work is under investigation

Bharat Aggarwal, the highly cited MD Anderson Cancer Center researcher who has confirmed to us that his work is under investigation by the institution, has a correction of his work in the Journal of Molecular Medicine. Troubled images are to blame — as they have been in previous retractions, and at least one other correction, of Aggarwal’s papers.

The paper, “Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor,” was published in December 2010 and cited 15 times since, according to Thomson Scientific’s Web of Knowledge.

Here’s the notice:

Correction for MD Anderson’s Bharat Aggarwal arches eyebrows for the right reasons

We’ve written about mega-corrections that allow scientists to retrace virtually all of their steps yet preserve their publications as supposedly legitimate. And we’ve seen plenty of corrections that allow authors to assert that their conclusions are correct when evidently important pieces of data are themselves unreliable.

Now comes a correction that seems to us to strike the right chords, given the fact that editors are to a large extent at the mercy of authors in these situations.

Another withdrawal by MD Anderson’s Aggarwal, again for unclear reasons

Bharat B. Aggarwal, the MD Anderson researcher under investigation at his institution over concerns of image manipulation, has withdrawn a second paper, although you’d never know why from the statement.

The notice for the article, “Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells,” is pretty minimal:

MD Anderson researcher Aggarwal loses paper in Cancer Letters

Whether it’s a one-off or a sign of things to come, Bharat Aggarwal, the MD Anderson scientist at the center of a blogospheric storm—and an institutional investigation—over the validity of his data, has had a paper withdrawn by the journal Cancer Letters.

MD Anderson investigating researcher Bharat Aggarwal over images

Bharat Aggarwal, an influential MD Anderson researcher who has been accused in the blogosphere of manipulating images in a slew of published studies, acknowledged to Retraction Watch that the Houston institution is investigating the matter. Reached by Retraction Watch by phone at his office, Aggarwal said MD Anderson

has been looking into it and I think that they will tell everybody what it is all about. I think that somebody out there is putting this whole thing together and their mind is made up.

However, Aggarwal, chief of the center’s cytokine research section, denied that any retractions of his papers were forthcoming. He refused to comment on whether officials had confiscated his computer, as a commenter to this blog has claimed.