Retraction 12 appears for Alirio Melendez, this one for plagiarism

The twelfth of Alirio Melendez’s 20-something retractions has appeared, in Clinical and Experimental Pharmacology and Physiology.

Along with the retraction notice, the journal runs letters from the paper’s two co-authors. Melendez writes:

Alirio Melendez notches retractions 10 and 11

Former National University of Singapore and University of Liverpool scientist Alirio Melendez has two more of the 20-something retractions suggested by the investigations into his work. Both appear in the Journal of Biological Chemistry.

Here’s the notice for “FcγRI-triggered generation of arachidonic acid and eicosanoids requires iPLA₂ but not cPLA₂ in human monocytic cells:”

Retraction nine appears for Alirio Melendez

An immunologist found by a former employer to have committed misconduct in more than 20 papers has had another paper retracted.

Here’s the notice for “Refining siRNA in vivo transfection: Silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo,” by Alirio Melendez and colleagues in The International Journal of Biochemistry & Cell Biology:

And then there were eight: Three more retractions for Alirio Melendez, all in the Journal of Immunology

Alirio Melendez, who has already retracted five papers and was found by one of his former universities to have committed misconduct on more than 20, has three more retractions.

Here’s the notice for “Antisense Knockdown of Sphingosine Kinase 1 in Human Macrophages Inhibits C5a Receptor-Dependent Signal Transduction, Ca²⁺ Signals, Enzyme Release, Cytokine Production, and Chemotaxis,” cited 68 times, according to Thomson Scientific’s Web of Knowledge:

NUS: Melendez committed “serious scientific misconduct,” but don’t expect to get any details

Alirio Melendez, a former National University of Singapore immunologist whose story we’ve been following here since a retraction in September of last year, committed misconduct on an “unprecedented” scale, according to the university, involving more than 20 papers.

Nature’s Richard van Noorden has the scoop:

After a 19-month investigation, the National University of Singapore (NUS) today says that it has determined that one of its former scientists, the immunologist Alirio Melendez, has committed “serious scientific misconduct”.  The university found fabrication, falsification or plagiarism associated with 21 papers, and no evidence indicating that other co-authors were involved in the misconduct, it says.

Melendez has retracted five papers so far, as we’ve reported, but NUS wouldn’t give the whole list. They tell Nature:

Fifth Alirio Melendez retraction offers clues about University of Glasgow misconduct findings

A new retraction — his fifth — in the Journal of Immunology for Alirio Melendez, formerly of the National University of Singapore, the University of Glasgow, and the University of Liverpool, sheds some light on the results of an investigation by one of the universities.

Last month, a Glasgow spokesperson told Nature that the university’s investigation had been completed in October 2011, but that it did not comment on individual cases. A spokesperson, according to the Times Higher Education:

…would say only that there was “no evidence that our current staff contributed, falsified or duplicated data to any publications co-authored with (Professor) Melendez”. He also confirmed that relevant journals would be contacted where retractions or corrections were deemed necessary.

The notice for one such necessary retraction, in the September 15 issue of the Journal of Immunology, gives a few details:

Retraction number four appears in PNAS for work of Alirio Melendez, who has resigned post at U Liverpool

Alirio Melendez, who has had three of his papers retracted amidst suspicions about 70, has had another one retracted, this one in the Proceedings of the National Academy of Sciences (PNAS). And he has also resigned from his post at the University of Liverpool, we have just learned.

Here’s the notice:

A correction for Alirio Melendez, in Journal of Cellular Physiology

We’ve been covering the case of Alirio Melendez, three of whose papers have been retracted amidst questions about almost 70 studies. The latest development is a correction in the Journal of Cellular Physiology, which has already retracted one of his papers, of a study on which he was a co-author.

Here’s the correction for “Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells”:

Third retraction arrives for Alirio Melendez, this one in the Journal of Cellular Physiology

Alirio Melendez, the former National University of Singapore researcher who has already retracted two papers in the midst of an investigation into about 70 of his publications, has had a third retracted a third.

Here’s the notice from the Journal of Cellular Physiology:

Second retraction arrives in Alirio Melendez case

Alirio Melendez, whose former employer, the National University of Singapore, is investigating about 70 of his papers, has retracted a second study. Here’s the notice for the 2010 Journal of Molecular Cell Biology paper, ”Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human Adult Bone Marrow and Adipose Tissue-derived Stem Cells:”