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	<title>Comments on: Why didn&#8217;t XMRV-chronic fatigue syndrome researcher Mikovits &#8212; now fired &#8212; share data with Science?</title>
	<atom:link href="http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/feed/" rel="self" type="application/rss+xml" />
	<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/</link>
	<description>Tracking retractions as a window into the scientific process</description>
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		<title>By: Tony Mach</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-9247</link>
		<dc:creator><![CDATA[Tony Mach]]></dc:creator>
		<pubDate>Wed, 25 Jan 2012 11:19:05 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-9247</guid>
		<description><![CDATA[You will find more here:
http://scienceblogs.com/erv/2011/09/xmrv_and_chronic_fatigue_syndr_28.php]]></description>
		<content:encoded><![CDATA[<p>You will find more here:<br />
<a href="http://scienceblogs.com/erv/2011/09/xmrv_and_chronic_fatigue_syndr_28.php" rel="nofollow">http://scienceblogs.com/erv/2011/09/xmrv_and_chronic_fatigue_syndr_28.php</a></p>
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		<title>By: Tony Mach</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-9246</link>
		<dc:creator><![CDATA[Tony Mach]]></dc:creator>
		<pubDate>Wed, 25 Jan 2012 11:11:49 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-9246</guid>
		<description><![CDATA[And BTW, the point seems to have been lost here: Robert Silverman reported to have found XMRV VP62 *plasmid*,  CMV promoter and all. 

As he writes:

&quot;It appears likely, therefore, that these XMRV sequences originated not from the patients but rather from the XMRV VP62 plasmid.&quot;


All the XMRV contamination that happened in other labs (or in cell lines for that matter) can be traced back to mice and were accidental. Either reagents or lab equipment was contaminated with trace amounts of MLV-like viruses, or cell lines were contaminated by MLVs by passage through mouse tissue. XMRV VP62 plasmid on the other hand is an artificial entity created for lab work and XMRV research. This makes an *accidental* contamination highly unlikely and it looks more like it was *put* there.]]></description>
		<content:encoded><![CDATA[<p>And BTW, the point seems to have been lost here: Robert Silverman reported to have found XMRV VP62 *plasmid*,  CMV promoter and all. </p>
<p>As he writes:</p>
<p>&#8220;It appears likely, therefore, that these XMRV sequences originated not from the patients but rather from the XMRV VP62 plasmid.&#8221;</p>
<p>All the XMRV contamination that happened in other labs (or in cell lines for that matter) can be traced back to mice and were accidental. Either reagents or lab equipment was contaminated with trace amounts of MLV-like viruses, or cell lines were contaminated by MLVs by passage through mouse tissue. XMRV VP62 plasmid on the other hand is an artificial entity created for lab work and XMRV research. This makes an *accidental* contamination highly unlikely and it looks more like it was *put* there.</p>
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		<title>By: Tony Mach</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-9245</link>
		<dc:creator><![CDATA[Tony Mach]]></dc:creator>
		<pubDate>Wed, 25 Jan 2012 10:55:34 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-9245</guid>
		<description><![CDATA[&quot;The only conclusion is that they were contaminated in the Cleveland Clinic. We decided not to throw them under the bus.&quot;

Funny that, because my impression is that Dr. Mikovits *is* throwing them under the bus with the accusation that it was the Cleveland Clinic that was contaminated. The statement should read &quot;We decided to throw them under the bus when it suited us.&quot;

And I wonder how the Cleveland Clinic managed to contaminate the samples in the WPI lab:
http://www.ncbi.nlm.nih.gov/nuccore?term=Khaiboullina]]></description>
		<content:encoded><![CDATA[<p>&#8220;The only conclusion is that they were contaminated in the Cleveland Clinic. We decided not to throw them under the bus.&#8221;</p>
<p>Funny that, because my impression is that Dr. Mikovits *is* throwing them under the bus with the accusation that it was the Cleveland Clinic that was contaminated. The statement should read &#8220;We decided to throw them under the bus when it suited us.&#8221;</p>
<p>And I wonder how the Cleveland Clinic managed to contaminate the samples in the WPI lab:<br />
<a href="http://www.ncbi.nlm.nih.gov/nuccore?term=Khaiboullina" rel="nofollow">http://www.ncbi.nlm.nih.gov/nuccore?term=Khaiboullina</a></p>
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		<title>By: Poodle Stomper</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-6887</link>
		<dc:creator><![CDATA[Poodle Stomper]]></dc:creator>
		<pubDate>Thu, 24 Nov 2011 17:26:41 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-6887</guid>
		<description><![CDATA[If a person with CFS (not necessarily you but other person) cannot afford the $40 dollars and thus cannot read the whole paper, then that person should likewise refrain from making ridiculous accusations.  Adobe acrobat has a fancy function called &quot;zoom in&quot;.  The images were the same and people that don&#039;t know what they&#039;re talking about shouldn&#039;t comment or make up things like Science going after ERV&#039;s gel image source (ironically the source is the Science paper).  However, I&#039;d also be interested in which paper you are referring to.  If you provide a reference I&#039;m sure any number of people would be interested.  I&#039;d also hope that you aren&#039;t putting stock in anecdotes.  Those are a dangerous thing.]]></description>
		<content:encoded><![CDATA[<p>If a person with CFS (not necessarily you but other person) cannot afford the $40 dollars and thus cannot read the whole paper, then that person should likewise refrain from making ridiculous accusations.  Adobe acrobat has a fancy function called &#8220;zoom in&#8221;.  The images were the same and people that don&#8217;t know what they&#8217;re talking about shouldn&#8217;t comment or make up things like Science going after ERV&#8217;s gel image source (ironically the source is the Science paper).  However, I&#8217;d also be interested in which paper you are referring to.  If you provide a reference I&#8217;m sure any number of people would be interested.  I&#8217;d also hope that you aren&#8217;t putting stock in anecdotes.  Those are a dangerous thing.</p>
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		<title>By: A. Cantwell</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-6810</link>
		<dc:creator><![CDATA[A. Cantwell]]></dc:creator>
		<pubDate>Tue, 22 Nov 2011 17:35:39 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-6810</guid>
		<description><![CDATA[I&#039;m sorry but I&#039;m not familiar with the papers which show that CFS patients respond to antiretroviral drugs can you provide references?  This is not my field of expertise so I&#039;m not fluent in the literature.]]></description>
		<content:encoded><![CDATA[<p>I&#8217;m sorry but I&#8217;m not familiar with the papers which show that CFS patients respond to antiretroviral drugs can you provide references?  This is not my field of expertise so I&#8217;m not fluent in the literature.</p>
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		<title>By: larry depuy</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-6762</link>
		<dc:creator><![CDATA[larry depuy]]></dc:creator>
		<pubDate>Mon, 21 Nov 2011 17:46:14 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-6762</guid>
		<description><![CDATA[As a person with CFS/ME I can&#039;t afford to pay 40 bucks to read an article, but, if what the outline indicates i.e. no gammaretrovirus is involved in CFS, then why are CFS patients responding to antiretroviral drugs?]]></description>
		<content:encoded><![CDATA[<p>As a person with CFS/ME I can&#8217;t afford to pay 40 bucks to read an article, but, if what the outline indicates i.e. no gammaretrovirus is involved in CFS, then why are CFS patients responding to antiretroviral drugs?</p>
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		<title>By: A. Cantwell</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-6128</link>
		<dc:creator><![CDATA[A. Cantwell]]></dc:creator>
		<pubDate>Fri, 28 Oct 2011 19:18:06 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-6128</guid>
		<description><![CDATA[Trends in Microbiology just published an interesting paper by a group at Imperial College London which addresses some of the scientific issues with the association between CFS and XMRV.  I definitely recommend it to anyone interested in this controversy. 

http://www.sciencedirect.com/science/article/pii/S0966842X11001636
 
Sorry if the link doesn&#039;t work, the reference is... Trends in Microbiology
Volume 19, Issue 11, November 2011, Pages 525-529.]]></description>
		<content:encoded><![CDATA[<p>Trends in Microbiology just published an interesting paper by a group at Imperial College London which addresses some of the scientific issues with the association between CFS and XMRV.  I definitely recommend it to anyone interested in this controversy. </p>
<p><a href="http://www.sciencedirect.com/science/article/pii/S0966842X11001636" rel="nofollow">http://www.sciencedirect.com/science/article/pii/S0966842X11001636</a></p>
<p>Sorry if the link doesn&#8217;t work, the reference is&#8230; Trends in Microbiology<br />
Volume 19, Issue 11, November 2011, Pages 525-529.</p>
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		<title>By: helen-louise</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-5342</link>
		<dc:creator><![CDATA[helen-louise]]></dc:creator>
		<pubDate>Wed, 05 Oct 2011 19:42:03 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-5342</guid>
		<description><![CDATA[I&#039;d be really interested to know how many biochemistry/molecular medicine articles have been retracted due to dodgy Southern or Western blots. They seem to be incredibly easy to fake. Import into Photoshop, whack the contrast of one line to the maximum, reduce the contrast of another line... Even better, take a genuine set of bands and simply change the labelling on the top!

It&#039;s making me worry about the integrity of the tool, which is a problem since virtually every medicinal chemistry paper I&#039;ve read uses one or more Western blots to &quot;prove&quot; the efficacy of a potential drug in vivo.]]></description>
		<content:encoded><![CDATA[<p>I&#8217;d be really interested to know how many biochemistry/molecular medicine articles have been retracted due to dodgy Southern or Western blots. They seem to be incredibly easy to fake. Import into Photoshop, whack the contrast of one line to the maximum, reduce the contrast of another line&#8230; Even better, take a genuine set of bands and simply change the labelling on the top!</p>
<p>It&#8217;s making me worry about the integrity of the tool, which is a problem since virtually every medicinal chemistry paper I&#8217;ve read uses one or more Western blots to &#8220;prove&#8221; the efficacy of a potential drug in vivo.</p>
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		<title>By: MattK</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-5284</link>
		<dc:creator><![CDATA[MattK]]></dc:creator>
		<pubDate>Tue, 04 Oct 2011 01:40:29 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-5284</guid>
		<description><![CDATA[&lt;blockquote&gt;Science is talking about the allegations against ERVs unnamed designer of the non blurry gels. As they would not have been in possession of the originals.&lt;/blockquote&gt;I&#039;ve seen some talk of this when I followed links to a couple CFI blogs and forums. It seems the allegations are the work of a nut (at least everyone (one person?) who is repeating them sure acts like a nut). First of all, it doesn&#039;t matter because the images are clearly of the same gel in Lombardi et al and in the Ottawa slides. Where they came from is a distraction from the main point. Second of all, I don&#039;t see the extra detail they keep talking about. Perhaps they are confused because the PDF that you can get behind the paywall has higher resolution figures than the reprint that&#039;s been circulating on the CFI forums. It also seems that, from the Tribune article, there is a non-jpeg copy of the Ottawa slideshow, presumably with higher resolution images (and original gel labels preserved?) circulating via email amongst some scientists.]]></description>
		<content:encoded><![CDATA[<blockquote><p>Science is talking about the allegations against ERVs unnamed designer of the non blurry gels. As they would not have been in possession of the originals.</p></blockquote>
<p>I&#8217;ve seen some talk of this when I followed links to a couple CFI blogs and forums. It seems the allegations are the work of a nut (at least everyone (one person?) who is repeating them sure acts like a nut). First of all, it doesn&#8217;t matter because the images are clearly of the same gel in Lombardi et al and in the Ottawa slides. Where they came from is a distraction from the main point. Second of all, I don&#8217;t see the extra detail they keep talking about. Perhaps they are confused because the PDF that you can get behind the paywall has higher resolution figures than the reprint that&#8217;s been circulating on the CFI forums. It also seems that, from the Tribune article, there is a non-jpeg copy of the Ottawa slideshow, presumably with higher resolution images (and original gel labels preserved?) circulating via email amongst some scientists.</p>
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		<title>By: Ham</title>
		<link>http://retractionwatch.wordpress.com/2011/10/03/why-didnt-xmrv-chronic-fatigue-syndrome-researcher-mikovits-now-fired-share-data-with-science/#comment-5283</link>
		<dc:creator><![CDATA[Ham]]></dc:creator>
		<pubDate>Tue, 04 Oct 2011 00:30:02 +0000</pubDate>
		<guid isPermaLink="false">http://retractionwatch.wordpress.com/?p=4636#comment-5283</guid>
		<description><![CDATA[Science is talking about the allegations against ERVs unnamed designer of the non blurry gels.  As they would not have been in possession of the originals.]]></description>
		<content:encoded><![CDATA[<p>Science is talking about the allegations against ERVs unnamed designer of the non blurry gels.  As they would not have been in possession of the originals.</p>
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